Calculus for Kinetic Modeling                                                                          Enzyme Kinetics
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EK Exercise 2.1.

[Maple Math]

[Maple Math]

[Maple Math]














EK Exercise 2.2.
Next, show that the equations:

[Maple Math]

can be derived, by using the equation for C(t) derived in EK Exercise2.1 above, together with the equations:

[Maple Math]














EK Exercise 2.3.
Show that when the P'(t) is half maximal, i.e. P'(t) = 0.5 x Vm, for some value of t, then the substrate level S(t) turns out to be equal to Km, for that same value of t. So, first substitute P'(t) = 0.5 x Vm into the Michaelis-Menten equation for P'(t) and then solve for S:

[Maple Math]















EK Exercise 2.4.
Define S(t) and P(t) using Lambert's W function, as in LW Exercise 1.4:

[Maple Math]

and then show that S(t) and P(t) satisfy the Michaelis-Menten Uptake equations.
 
 
 
 
 
 
 
 
 
 
 
 
 
 

EK Exercise 2.5.
Also, define S(t) and P(t) using Lambert's W function, as in LW Exercise 1.6:

[Maple Math]

and then show that S(t) and P(t) satisfy the Michaelis-Menten Uptake equations. Which of the two different definitions of S(t) and P(t), given here in and in the last problem above, provide the best model? Explain why you would choose one over the other.